Руните в Diablo II са малки камъни гравирани с магически символи, които могат да се прилагат към предмети с дупки (Socketed Items). Руните могат да се комбинират (Rune Words), като в правилния ред и комбинация дават на предметите нови допълнителни свойства, променят името на предмета и неговия цвят.

• Често срещани руни (от най-често срещаните до по-рядко срещаните):
  • El, Eld, Tir, Nef, Eth, Ith, Tal, Ral, Ort, Amn, Shael, Thul

• Полу-редки руни:
  • Sol, Dol, Hel, Io, Lum, Ko, Fal, Lem, Pul, Um

• Супер редки руни:
  • Mal, Ist, Gul, Vex, Ohm, Lo, Sur, Ber, Jah, Cham, Zod

Име	Крафтване	Ефект	Левел
El	-	Оръжие: +50 To Attack Rating, +1 Light Radius Armor/Helms/Shields: +15 Defense, +1 To Light Radius	11
Eld	3x El	Оръжие: +75% Damage To Undead, +50 Attack Rating Against Undead Armor/Helms/Shields: 15% Slower Stamina Drain/7% Increased Chance of Blocking(Shields)	11
Tir	3x Eld	Оръжие: +2 To Mana After Each Kill Armor/Helms/Shields: +2 To Mana After Each Kill	13
Nef	3x Tir	Оръжие: Knockback Armor/Helms/Shields: +30 Defense Vs. Missile	13
Eth	3x Nef	Оръжие: -25% To Target Defense Armor/Helms/Shields: Regenerate Mana 15%	15
Ith	3x Eth	Оръжие: +9 To Maximum Damage Armor/Helms/Shields: 15% Damage Taken Goes to Mana	15
Tal	3x Ith	Оръжие: +75 Poison Damage Over 5 Seconds Armor/Helms/Shields: Poison Resist 30%/Poison Resist 35%(Shields)	17
Ral	3x Tal	Оръжие: Adds 5-30 Fire Damage Armor/Helms/Shields: Fire Resist 30%/Fire Resist 35%(Shields)	19
Ort	3x Ral	Оръжие: Adds 1-50 Lightning Damage Armor/Helms/Shields: Lightning Resist 30%/Lightning Resist 35%(Shields)	21
Thul	3x Ort	Оръжие: Adds 3-14 Cold Damage - 3 Second Duration Armor/Helms/Shields: Cold Resist 30%/Cold Resist 35%(Shields)	23
Amn	3x Thul + chipped Topaz	Оръжие: 7% Life Stolen Per Hit Armor/Helms/Shields: Attacker Takes Damage of 14	25
Sol	3x Amn + chipped Amethyst	Оръжие: +9 To Minimum Damage Armor/Helms/Shields: Damage Reduced By 7	27
Shael	3x Sol + chipped Sapphire	Оръжие: 20% Increased Attack Speed Armor/Helms/Shields: 20% Faster Hit Recovery/20% Faster Block Rate(Shields)	29
Dol	3x Shael + chipped Ruby	Оръжие: Hit Causes Monster To Flee 25% Armor/Helms/Shields: Replenish Life +7	31
Hel	3x Dol + chipped Emerald	Оръжие: Requirements -20% Armor/Helms/Shields: Requirements -15%	-
Io	3x Hel + chipped Diamond	Оръжие: +10 To Vitality Armor/Helms/Shields: +10 To Vitality	35
Lum	3x Io + flawed Topaz	Оръжие: +10 To Energy Armor/Helms/Shields: +10 To Energy	37
Ko	3x Lum + flawed Amethyst	Оръжие: +10 To Dexterity Armor/Helms/Shields: +10 To Dexterity	39
Fal	3x Ko + flawed Sapphire	Оръжие: +10 To Strength Armor/Helms/Shields: +10 To Strength	41
Lem	3x Fal + flawed Ruby	Оръжие: 75% Extra Gold From Monsters Armor/Helms/Shields: 50% Extra Gold From Monsters	43
Pul	3x Lem + flawed Emerald	Оръжие: +75% Damage To Demons, +100 Attack Rating Against Demons Armor/Helms/Shields: +30% Enhanced Defense	45
Um	2x Pul + flawed Diamond	Оръжие: 25% Chance of Open Wounds Armor/Helms/Shields: All Resistances +15(Armor/Helms) +22(Shields)	47
Mal	2x Um + normal Topaz	Оръжие: Prevent Monster Heal Armor/Helms/Shields: Magic Damage Reduced By 7	49
Ist	2x Mal + normal Amethyst	Оръжие: 30% Better Chance of Getting Magic Items Armor/Helms/Shields: 25% Better Chance of Getting Magic Items	51
Gul	2x Ist + normal Sapphire	Оръжие: 20% Bonus To Attack Rating Armor/Helms/Shields: 5% To Maximum Poison Resist	53
Vex	2x Gul + normal Ruby	Оръжие: 7% Mana Stolen Per Hit Armor/Helms/Shields: 5% To Maximum Fire Resist	55
Ohm	2x Vex + normal Emerald	Оръжие: +50% Enhanced Damage Armor/Helms/Shields: 5% To Maximum Cold Resist	57
Lo	2x Ohm + normal Diamond	Оръжие: 20% Deadly Strike Armor/Helms/Shields: 5% To Maximum Lightning Resist	59
Sur	2x Lo + flawless Topaz	Оръжие: Hit Blinds Target Armor/Helms/Shields: Maximum Mana 5%/+50 To Mana (Shields)	61
Ber	2x Sur + flawless Amethyst	Оръжие: 20% Chance of Crushing Blow Armor/Helms/Shields: Damage Reduced by 8%	63
Jah	2x Ber + flawless Sapphire	Оръжие: Ignore Target's Defense Armor/Helms/Shields: Increase Maximum Life 5%/+50 Life (Shields)	65
Cham	2x Jah + flawless Ruby	Оръжие: Freeze Target +3 Armor/Helms/Shields: Cannot Be Frozen	67
Zod	2x Cham + flawless Emerald	Оръжие: Indestructible Armor/Helms/Shields: Indestructible	69